Abstract
Experimental islet transplantations in pancreatectomized and streptozotocin-treated
diabetic allogeneic and partially inbred rats are considered with respect to transplantation
site and immunological factors responsible for survival. It could be shown that transplantation
into the liver and into the lung in both systems (allogeneic and partially inbred)
was accompanied by longer survival of the islets compared with the following regions:
subcutaneous tissue, muscle, epididymal fat tissue, peritoneal cavity.
This indicates that not only immunological but also factors of blood supply (oxygen
consumption? ) play a role in the survival of the grafts. - The success of transplantation
depends mainly on histocompatibility. Partially inbred rats showed significantly longer
survival of islets than non-inbred rats. The studies of other groups using similar
experimental models are reviewed.
Key words
Experimental Diabetes - Streptozotocin - Pancreatectomy - Islet Transplantation -
I. V. Glucose Tolerance Test - Survival Period - Histocompatibility
1 Supported by Deutsche Forschungsgemeinschaft SFB 87 Grand (D) 7 Ulm
2 Institute "Rudjer Bošković", Zagreb, Yugoslavia
